|Application ||IHC-P, E|
|Other Accession||P25235, Q9GL01, Q3SZI6, NP_002942|
|Predicted||Bovine, Pig, Rat|
|Calculated MW||69284 Da|
|Antigen Region||16-46 aa|
|Other Names||Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit, RIBIIR, Ribophorin II, RPN-II, Ribophorin-2, RPN2|
|Target/Specificity||This Ribophorin 2 (RPN2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human Ribophorin 2 (RPN2).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Ribophorin 2 (RPN2) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in all tissues tested.|
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Provided below are standard protocols that you may find useful for product applications.
RNP2 a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1.
Kelleher, D.J., et al., Mol. Cell 12(1):101-111 (2003). Fu, J., et al., J. Biol. Chem. 275(6):3984-3990 (2000). Loffler, C., et al., Hum. Genet. 87(2):221-222 (1991). Crimaudo, C., et al., EMBO J. 6(1):75-82 (1987). Stoffel, M., et al., Hum. Mol. Genet. 1 (8), 656 (1992).
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