- CITATIONS: 3
|Application ||WB, IHC-P, E|
|Other Accession||Q80W54, NP_005848|
|Calculated MW||54813 Da|
|Antigen Region||400-430 aa|
|Other Names||CAAX prenyl protease 1 homolog, Farnesylated proteins-converting enzyme 1, FACE-1, Prenyl protein-specific endoprotease 1, Zinc metalloproteinase Ste24 homolog, ZMPSTE24, FACE1, STE24|
|Target/Specificity||This ZMPSTE24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-430 amino acids from the Central region of human ZMPSTE24.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZMPSTE24 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed. High levels in kidney, prostate, testis and ovary|
Provided below are standard protocols that you may find useful for product applications.
ZMPSTE24 is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It is thought to be involved in the proteolytic processing of farnesylated proteins.
Freije, J.M., et al., Genomics 58(3):270-280 (1999).
Kumagai, H., et al., Biochim. Biophys. Acta 1426(3):468-474 (1999).
Tam, A., et al., J. Cell Biol. 142(3):635-649 (1998).
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