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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   GGPS1 Antibody (C-term)   

GGPS1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GGPS1 Antibody (C-term) AP2419B
    Western blot analysis ofGGPS1 Antibody (C-term) (Cat. #AP2419b) in mouse cerbellum tissue lysates (35ug/lane). GGPS1 (arrow) was detected using the purified Pab.
  • IHC-P - GGPS1 Antibody (C-term) AP2419B
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with GGPS1 Antibody (C-term)(AP2419b), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95749
Other Accession NP_004828
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 34871 Da
Antigen Region 270-300 aa
Additional Information
Gene ID 9453
Other Names Geranylgeranyl pyrophosphate synthase, GGPP synthase, GGPPSase, 251-, (2E, 6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Farnesyltranstransferase, Geranylgeranyl diphosphate synthase, Geranyltranstransferase, GGPS1
Target/Specificity This GGPS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-300 amino acids from the C-terminal region of human GGPS1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGGPS1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GGPS1
Function Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Cellular Location Cytoplasm.
Tissue Location Abundantly expressed in testis. Found in other tissues to a lower extent
Research Areas
Citations ( 0 )


Geranylgeranyl diphosphate (GGPP) synthase (GGPS) catalyzes the synthesis of GGPP, a molecule responsible for the C20-prenylation of protein and for the regulation of a nuclear hormone receptor. The deduced 300-amino acid human protein contains 5 conserved domains consistent with prenyltransferases. Recombinant GGPS shows enzymatic properties associated with the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. Mouse GGPS is regulated in several tissues in obesity and is induced during adipocyte differentiation. GGPS is increased 5- to 20-fold in skeletal muscle, liver, and fat of ob/ob mice. Western blot analysis detects a 2-fold overexpression of protein in muscle and fat but not in liver. Differentiation of mouse fibroblasts into adipocytes induces GGPS expression more than 20-fold.


Kainou, T., et al., Biochim. Biophys. Acta 1437(3):333-340 (1999).
Kuzuguchi, T., et al., J. Biol. Chem. 274(9):5888-5894 (1999).
Ericsson, J., et al., J. Lipid Res. 39(9):1731-1739 (1998).

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$ 295.00
$ 99.00
Cat# AP2419B
(40 western blots)
Availability: In Stock
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