|Application ||WB, E|
|Calculated MW||57419 Da|
|Antigen Region||200-231 aa|
|Other Names||E3 ubiquitin-protein ligase TRIM69, 632-, RFP-like domain-containing protein trimless, RING finger protein 36, Tripartite motif-containing protein 69, TRIM69, RNF36|
|Target/Specificity||This RNF36 (TRIM69) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-231 amino acids from the Central region of human RNF36 (TRIM69).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNF36 (TRIM69) Antibody (Center H215) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus speckle|
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Provided below are standard protocols that you may find useful for product applications.
TRIM69 is a member of the RING-B-box-coiled-coil (RBCC) family with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of TRIM69 is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis.
Shyu,H.W., Exp. Cell Res. 287 (2), 301-313 (2003)
Shyu,H.W., Mech. Dev. 108 (1-2), 213-216 (2001)
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