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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   ICMT (C-term) Antibody   

ICMT (C-term) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ICMT (C-term) Antibody AP2543b
    The anti-ICMT Pab (Cat. #AP2543b) is used in Western blot to detect ICMT in T47D (left) and SK-BR-3 (right) tissue lysate
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O60725
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31938 Da
Antigen Region 250-284 aa
Additional Information
Gene ID 23463
Other Names Protein-S-isoprenylcysteine O-methyltransferase, Isoprenylcysteine carboxylmethyltransferase, Prenylated protein carboxyl methyltransferase, PPMT, Prenylcysteine carboxyl methyltransferase, pcCMT, ICMT, PCCMT
Target/Specificity This ICMT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-284 amino acids from the C-terminal region of human ICMT.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsICMT (C-term) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ICMT
Synonyms PCCMT
Function Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein
Tissue Location Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions Abundant expression seen in the Purkinje cells and pontine neurons.
Research Areas
Citations (0)

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Background

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing results in two transcript variants encoding different isoforms.

References

Bergo, M.O., et al., J. Clin. Invest. 113(4):539-550 (2004).
Ahmad, M., et al., Arterioscler. Thromb. Vasc. Biol. 22(5):759-764 (2002).
Van Dessel, G.A., et al., Int. J. Biochem. Cell Biol. 34(5):477-486 (2002).
Dai, Q., et al., J. Biol. Chem. 273(24):15030-15034 (1998).

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Cat# AP2543b
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(40 western blots)
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