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> home > Products > Primary Antibodies > Antibody Collections > Anti-Wnt-Pathway (plus Lgr5) Antibodies > DAAM1 Antibody (N-term)
DAAM1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9Y4D1 |
| Other Accession | Q8BPM0 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 123473 Da |
| Antigen Region | 45-74 aa |
| Gene ID | 23002 |
|---|---|
| Other Names | Disheveled-associated activator of morphogenesis 1, DAAM1, KIAA0666 |
| Target/Specificity | This DAAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-74 amino acids from the N-terminal region of human DAAM1. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DAAM1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DAAM1 |
|---|---|
| Synonyms | KIAA0666 |
| Function | Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (By similarity). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Perinuclear. Colocalizes with RHOA and KANK1 around centrosomes. {ECO:0000250|UniProtKB:Q8BPM0} |
| Tissue Location | Expressed in all tissues examined. |
Research Areas
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$ 192.50
Cat# AP2720a
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