|Application ||WB, IHC-P, E|
|Calculated MW||123603 Da|
|Antigen Region||940-969 aa|
|Other Names||Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2, ADCY2, KIAA1060|
|Target/Specificity||This ADCY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 940-969 amino acids from the C-terminal region of human ADCY2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADCY2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
ADCY2 is a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate(cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
Uhl,G.R.,Arch. Gen. Psychiatry 65 (6), 683-693 (2008)
Ludwig,M.G.,J. Recept. Signal Transduct. Res. 22 (1-4), 79-110 (2002)
Cote,M., J. Clin. Endocrinol. Metab. 86 (9), 4495-4503 (2001)
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