|Application ||WB, IHC-P, E|
|Calculated MW||123603 Da|
|Antigen Region||940-969 aa|
|Other Names||Adenylate cyclase type 2, ATP pyrophosphate-lyase 2, Adenylate cyclase type II, Adenylyl cyclase 2, ADCY2, KIAA1060|
|Target/Specificity||This ADCY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 940-969 amino acids from the C-terminal region of human ADCY2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADCY2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein. Cell membrane; Multi- pass membrane protein. Cytoplasm|
|Tissue Location||Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ADCY2 is a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate(cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
Uhl,G.R.,Arch. Gen. Psychiatry 65 (6), 683-693 (2008)
Ludwig,M.G.,J. Recept. Signal Transduct. Res. 22 (1-4), 79-110 (2002)
Cote,M., J. Clin. Endocrinol. Metab. 86 (9), 4495-4503 (2001)
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