|Application ||WB, IHC-P, E|
|Other Accession||P48675, P02540, P31001, O62654|
|Predicted||Bovine, Mouse, Pig, Rat|
|Calculated MW||53536 Da|
|Antigen Region||1-30 aa|
|Other Names||Desmin, DES|
|Target/Specificity||This Desmin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human Desmin.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Desmin Antibody (T16) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.|
|Cellular Location||Cytoplasm. Cell membrane, sarcolemma|
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Provided below are standard protocols that you may find useful for product applications.
Desmin is a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in the gene encoding desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Ariza,A., Hum. Pathol. 26 (9), 1032-1037 (1995)
Li,Z.L., Gene 78 (2), 243-254 (1989)
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