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FZD1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FZD1 Antibody (C-term) AP2755B
    Western blot analysis of anti-FZD1 Antibody (C-term) (Cat.#AP2755b) in Jurkat cell line lysates (35ug/lane).FZD1(arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UP38
Other Accession Q61090, O75084, O57329, Q8AVJ9, Q9PUK8, Q9I9M5, Q08463, O70421, O57328
Reactivity Human
Predicted Mouse, Rat, Chicken, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 71158 Da
Antigen Region 504-533 aa
Additional Information
Gene ID 8321
Other Names Frizzled-1, Fz-1, hFz1, FzE1, FZD1
Target/Specificity This FZD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 504-533 amino acids from the C-terminal region of human FZD1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFZD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD1
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.
Cellular Location Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney
Research Areas
Citations ( 0 )


Members of the 'frizzled' proten family are 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif.The FZD1 transcript is expressed in various tissues.


Quelard,D., (er) PLoS ONE 3 (4), E1878 (2008)
Hardie,W.D.,Am. J. Respir. Cell Mol. Biol. 37 (3), 309-321 (2007)
Yang,L., J. Dermatol. Sci. 42 (2), 111-119 (2006)

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$ 295.00
$ 99.00
Cat# AP2755B
(40 western blots)
Availability: In Stock
Bulk Size
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