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ZIC3 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O60481 |
| Other Accession | Q62521 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50569 Da |
| Antigen Region | 4-32 aa |
| Gene ID | 7547 |
|---|---|
| Other Names | Zinc finger protein ZIC 3, Zinc finger protein 203, Zinc finger protein of the cerebellum 3, ZIC3, ZNF203 |
| Target/Specificity | This ZIC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human ZIC3. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZIC3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZIC3 |
|---|---|
| Synonyms | ZNF203 |
| Function | Acts as a transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC- 3'. |
| Cellular Location | Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity) Translocation to the nucleus requires KPNA1 or KPNA6. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZIC3 is a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in the gene encoding ZIC3 cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.
References
Zhu,L., Hum. Mutat. 29 (1), 99-105 (2008)
Zhu,L., Hum. Mol. Genet. 16 (14), 1649-1660 (2007)
Bedard,J.E., Hum. Mol. Genet. 16 (2), 187-198 (2007)
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