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ZIC3 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ZIC3 Antibody (N-term) AP2761a
    Western blot analysis of anti-ZIC3 Antibody (N-term) (Cat.#AP2761a) in HL60 cell line lysates (35ug/lane).ZIC3(arrow) was detected using the purified Pab.
  • IHC-P - ZIC3 Antibody (N-term) AP2761a
    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ZIC3 antibody (N-term) (Cat.#AP2761a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60481
Other Accession Q62521
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50569 Da
Antigen Region 4-32 aa
Additional Information
Gene ID 7547
Other Names Zinc finger protein ZIC 3, Zinc finger protein 203, Zinc finger protein of the cerebellum 3, ZIC3, ZNF203
Target/Specificity This ZIC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human ZIC3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsZIC3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ZIC3
Synonyms ZNF203
Function Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
Cellular Location Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.
Research Areas
Citations (0)

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ZIC3 is a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in the gene encoding ZIC3 cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.


Zhu,L., Hum. Mutat. 29 (1), 99-105 (2008)
Zhu,L., Hum. Mol. Genet. 16 (14), 1649-1660 (2007)
Bedard,J.E., Hum. Mol. Genet. 16 (2), 187-198 (2007)

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Cat# AP2761a
(40 western blots)
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