|Application ||WB, IHC-P, FC, E|
|Calculated MW||95115 Da|
|Antigen Region||228-258 aa|
|Other Names||Disks large-associated protein 5, DAP-5, Discs large homolog 7, Disks large-associated protein DLG7, Hepatoma up-regulated protein, HURP, DLGAP5, DLG7, KIAA0008|
|Target/Specificity||This DLG7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-258 amino acids from the Central region of human DLG7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DLG7 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells|
|Tissue Location||Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta|
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Provided below are standard protocols that you may find useful for product applications.
DLG7 is potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. DLG7 is mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. DLG7 is key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
de Reynies, A., et al. J. Clin. Oncol. 27(7):1108-1115(2009) Wong, J., et al. Mol. Biol. Cell 19(5):2083-2091(2008) Gudmundsson, K.O., et al. Stem Cells 25(6):1498-1506(2007)
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