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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IRF8 Antibody (C-term)   

IRF8 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IRF8 Antibody (C-term) AP2830b
    Western blot analysis of anti-IRF8 Antibody (C-term) (Cat.#AP2830b) in HL60 cell line lysates (35ug/lane). IRF8 (arrow) was detected using the purified Pab.
  • FC - IRF8 Antibody (C-term) AP2830b
    IRF8 Antibody (C-term) (Cat. #AP2830b) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02556
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48356 Da
Antigen Region 384-409 aa
Additional Information
Gene ID 3394
Other Names Interferon regulatory factor 8, IRF-8, Interferon consensus sequence-binding protein, H-ICSBP, ICSBP, IRF8, ICSBP1
Target/Specificity This IRF8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-409 amino acids from the C-terminal region of human IRF8.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIRF8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IRF8
Synonyms ICSBP1
Function Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).
Cellular Location Nucleus.
Tissue Location Predominantly expressed in lymphoid tissues.
Research Areas
Citations (0)

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Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.


McGough,J.M., Mol. Cancer Res. 6 (12), 1841-1851 (2008)
Tshuikina,M., Exp. Hematol. 36 (12), 1673-1681 (2008)
Martinez,A., Am. J. Surg. Pathol. 32 (8), 1190-1200 (2008)

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$ 295.00
$ 99.00
Cat# AP2830b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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