|Application ||WB, IHC-P, FC, E|
|Other Accession||P62315, Q4R5F6, Q3ZC10|
|Predicted||Bovine, Monkey, Mouse|
|Calculated MW||13282 Da|
|Antigen Region||69-98 aa|
|Other Names||Small nuclear ribonucleoprotein Sm D1, Sm-D1, Sm-D autoantigen, snRNP core protein D1, SNRPD1|
|Target/Specificity||This SNRPD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-98 amino acids from the C-terminal region of human SNRPD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNRPD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP- snRNP interactions through nonspecific electrostatic contacts with RNA.|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes|
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Provided below are standard protocols that you may find useful for product applications.
SNRPD1 is a small nuclear ribonucleoprotein that belongs to the SNRNP core protein family. This protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA.
Lehner,B., Genome Res. 14 (7), 1315-1323 (2004)
Will,C.L., RNA 10 (6), 929-941 (2004)
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