|Application ||WB, FC, E|
|Calculated MW||40030 Da|
|Antigen Region||132-161 aa|
|Other Names||Coxsackievirus and adenovirus receptor, CAR, hCAR, CVB3-binding protein, Coxsackievirus B-adenovirus receptor, HCVADR, CXADR, CAR|
|Target/Specificity||This CXADR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-161 amino acids from the Central region of human CXADR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CXADR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single- pass type I membrane protein. Cell junction, tight junction. Cell junction, adherens junction. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions (PubMed:12297051). In airway epithelial cells localized to basolateral membrane but not to apical surface (PubMed:11316797). Isoform 4: Secreted|
|Tissue Location||Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CXADR is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses.
Tomko R.P., Xu R., Philipson L.Proc. Natl. Acad. Sci. U.S.A. 94:3352-3356(1997)
Bowles K.R., Gibson J.,Hum. Genet. 105:354-359(1999)
Fechner H., Haack A., Wang H., Wang X.Gene Ther. 6:1520-1535(1999)
Martino T.A., Petric M., Weingartl H.Virology 271:99-108(2000)
Ashbourne-Excoffon K.J.D., Hruska-Hageman A.M.J. Cell Sci. 117:4401-4409(2004)
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