|Application ||WB, E|
|Calculated MW||35349 Da|
|Antigen Region||156-184 aa|
|Other Names||Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38, Protein JTV-1, AIMP2, JTV1|
|Target/Specificity||This JTV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from the Central region of human JTV1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||JTV1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down- regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.|
|Cellular Location||Cytoplasm, cytosol. Nucleus. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
JTV1 is probable core protein of the multisynthetase complex that serves as a template for the assembly of the supramolecular structure. This protein Mediates ubiquitination of FUBP1 and its degradation by the proteasome.
Nicolaides N.C., Kinzler K.W., Vogelstein B.Genomics 29:329-334(1995)
Kim M.J., Park B.-J., Kang Y.-S., Kim H.J., Park J.-H., Kang J.W., Lee S.W.,
Nat. Genet. 34:330-336(2003)
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