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>   home   >   Products   >   Primary Antibodies   >   EXO1 Antibody (N-term)   

EXO1 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - EXO1 Antibody (N-term) AP2871a
    Western blot analysis of anti-EXO1 Antibody (N-term) (Cat.#AP2871a) in NCI-H460 cell line lysates (35ug/lane). EXO1 (arrow) was detected using the purified Pab.
  • IF - EXO1 Antibody (N-term) AP2871a
    Confocal immunofluorescent analysis of EXO1 Antibody (N-term) (Cat. #AP2871a) with A549 cell followed by Alexa Fluor® 489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UQ84
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 94103 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 9156
Other Names Exonuclease 1, hExo1, 31--, Exonuclease I, hExoI, EXO1, EXOI, HEX1
Target/Specificity This EXO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human EXO1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEXO1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EXO1
Synonyms EXOI, HEX1
Function 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Cellular Location Nucleus Note=Colocalizes with PCNA to discrete nuclear foci in S-phase
Tissue Location Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach
Citations (0)

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EXO1 is a protein with 5' to 3' exonuclease activity as well as an RNase H activity. This protein is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination.


Tishkoff D.X., Amin N.S., Viars C.S.Cancer Res. 58:5027-5031(1998)
Lee B.-I., Nguyen L.H.,Nucleic Acids Res. 30:942-949(2002)
Alam N.A., Gorman P., Jaeger E.E.M.Cancer Genet. Cytogenet. 147:121-127(2003)
Knudsen N.O., Nielsen F.C., Vinther L.Nucleic Acids Res. 35:2609-2619(2007)

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$ 295.00
$ 99.00
Cat# AP2871a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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