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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CD105 Antibody (Center E395)   

CD105 Antibody (Center E395)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CD105 Antibody (Center E395) AP2880C
    Western blot analysis of CD105 antibody (Center E395) (Cat. #AP2880c) in mouse heart tissue lysates (35ug/lane). CD105 (arrow) was detected using the purified Pab.
  • IHC-P - CD105 Antibody (Center E395) AP2880C
    CD105 antibody (Center E395) (Cat. #AP2880c) immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CD105 antibody (Center E395) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - CD105 Antibody (Center E395) AP2880C
    Flow cytometric analysis of NCI-H292 cells using CD105 Antibody (Center E395)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17813
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 70578 Da
Antigen Region 380-409 aa
Additional Information
Gene ID 2022
Other Names Endoglin, CD105, ENG, END
Target/Specificity This CD105 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the Central region of human CD105.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD105 Antibody (Center E395) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ENG
Synonyms END
Function Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Endoglin is restricted to endothelial cells in all tissues except bone marrow
Research Areas
Citations (0)

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CD105 is a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in its gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.


Chen,Y., Ann. Neurol. 66 (1), 19-27 (2009)
Rius,C., Blood 92 (12), 4677-4690 (1998)

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Cat# AP2880C
(40 western blots)
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