|Application ||WB, IHC-P, FC, E|
|Calculated MW||70578 Da|
|Antigen Region||380-409 aa|
|Other Names||Endoglin, CD105, ENG, END|
|Target/Specificity||This CD105 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the Central region of human CD105.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD105 Antibody (Center E395) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Endoglin is restricted to endothelial cells in all tissues except bone marrow|
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Provided below are standard protocols that you may find useful for product applications.
CD105 is a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in its gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.
Chen,Y., Ann. Neurol. 66 (1), 19-27 (2009)
Rius,C., Blood 92 (12), 4677-4690 (1998)
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