|Application ||WB, IHC-P, FC, E|
|Other Accession||O35112, O46651, Q61490, Q9BH13|
|Predicted||Bovine, Mouse, Rabbit, Rat|
|Calculated MW||65102 Da|
|Antigen Region||58-87 aa|
|Other Names||CD166 antigen, Activated leukocyte cell adhesion molecule, CD166, ALCAM, MEMD|
|Target/Specificity||This CD166 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-87 amino acids from the N-terminal region of human CD166.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD166 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
CD166 is cell adhesion molecule that binds to CD6. The protein is involved in neurite extension by neurons via heterophilic and homophilic interactions. It may play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
Kahlert,C., Br. J. Cancer 101 (3), 457-464 (2009)
Kulasingam,V., Int. J. Cancer 125 (1), 9-14 (2009)
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