|Application ||WB, IHC-P, FC, E|
|Other Accession||Q4R963, Q3T0K2|
|Calculated MW||60534 Da|
|Antigen Region||509-536 aa|
|Other Names||T-complex protein 1 subunit gamma, TCP-1-gamma, CCT-gamma, hTRiC5, CCT3, CCTG, TRIC5|
|Target/Specificity||This CCT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-536 amino acids from the C-terminal region of human CCT3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCT3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.|
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Provided below are standard protocols that you may find useful for product applications.
CCT3 is a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin.
Zebol,J.R., Int. J. Biochem. Cell Biol. 41 (4), 822-827 (2009)
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