|Application ||WB, IHC-P, FC, E|
|Other Accession||Q4V7C7, Q99JY9, Q90WD0, P61157|
|Predicted||Bovine, Chicken, Mouse, Rat|
|Calculated MW||47371 Da|
|Antigen Region||380-407 aa|
|Other Names||Actin-related protein 3, Actin-like protein 3, ACTR3, ARP3|
|Target/Specificity||This ACTR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-407 amino acids from the C-terminal region of human ACTR3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACTR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554)|
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Provided below are standard protocols that you may find useful for product applications.
ACTR3 is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.
Weisswange,I., et. al., Nature 458 (7234), 87-91 (2009)
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