- CITATIONS: 1
|Application ||IHC-P, WB, FC, IF, E|
|Other Accession||O08557, Q9CWS0, P56965|
|Calculated MW||31122 Da|
|Antigen Region||221-250 aa|
|Other Names||N(G), N(G)-dimethylarginine dimethylaminohydrolase 1, DDAH-1, Dimethylarginine dimethylaminohydrolase 1, DDAHI, Dimethylargininase-1, DDAH1, DDAH|
|Target/Specificity||This DDAH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-250 amino acids from the C-terminal region of human DDAH1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DDAH1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.|
|Tissue Location||Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle|
Provided below are standard protocols that you may find useful for product applications.
DDAH1 plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity.
Ellger,B., et.al., Endocrinology 149 (6), 3148-3157 (2008)
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