WDR1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O75083 |
Other Accession | Q2KJH4 |
Reactivity | Human |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 66194 Da |
Antigen Region | 548-577 aa |
Gene ID | 9948 |
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Other Names | WD repeat-containing protein 1, Actin-interacting protein 1, AIP1, NORI-1, WDR1 |
Target/Specificity | This WDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-577 amino acids from the C-terminal region of human WDR1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | WDR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | WDR1 |
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Function | Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). |
Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5RKI0}. Cell projection, podosome. Cell junction |
Tissue Location | Expressed in peripheral blood mononuclear cells (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
WDR1 is a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. This protein may help induce the disassembly of actin filaments.
References
McArdle,P.F., et.al., Arthritis Rheum. 58 (9), 2874-2881 (2008)
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