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>   home   >   Products   >   Primary Antibodies   >   STRAP Antibody (C-term)   

STRAP Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - STRAP Antibody (C-term) AP2933b
    Western blot analysis of STRAP Antibody (C-term) (Cat. #AP2933b) in Hela cell line lysates (35ug/lane). STRAP (arrow) was detected using the purified Pab.
  • IHC-P - STRAP Antibody (C-term) AP2933b
    Formalin-fixed and paraffin-embedded human brain tissue reacted with STRAP Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - STRAP Antibody (C-term) AP2933b
    Flow cytometric analysis of hela cells using STRAP Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • WB - STRAP Antibody (C-term) AP2933b
    Western blot analysis of STRAP (arrow) using rabbit polyclonal STRAP Antibody (C-term) (Cat. #AP2933b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the STRAP gene.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y3F4
Other Accession Q5XIG8, Q9Z1Z2, Q5ZL33, Q5E959
Reactivity Human
Predicted Bovine, Chicken, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38438 Da
Antigen Region 242-269 aa
Additional Information
Gene ID 11171
Other Names Serine-threonine kinase receptor-associated protein, MAP activator with WD repeats, UNR-interacting protein, WD-40 repeat protein PT-WD, STRAP, MAWD, UNRIP
Target/Specificity This STRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-269 amino acids from the C-terminal region of human STRAP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSTRAP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MAWD, UNRIP
Function The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
Cellular Location Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus
Citations (0)

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The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex.


Adams,C.J.,, EMBO Rep. 9 (12), 1222-1229 (2008)

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$ 295.00
$ 99.00
Cat# AP2933b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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