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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Klotho Antibody (C-term)   

Klotho Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Klotho Antibody (C-term) AP2945b
    Western blot analysis of Klotho Antibody (C-term) (Cat. #AP2945b) in K562 cell line lysates (35ug/lane). Klotho (arrow) was detected using the purified Pab.
  • FC - Klotho Antibody (C-term) AP2945b
    Flow cytometric analysis of K562 cells using Klotho Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UEF7
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 116181 Da
Antigen Region 986-1012 aa
Additional Information
Gene ID 9365
Other Names Klotho, Klotho peptide, KL
Target/Specificity This Klotho antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 986-1012 amino acids from the C-terminal region of human Klotho.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKlotho Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KL
Function May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Isoform 1 shedding leads to a soluble peptide Klotho peptide: Secreted.
Tissue Location Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney
Research Areas
Citations ( 0 )


Klotho is a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.


Sugiyama,N.,, Mol. Cell Proteomics 6 (6), 1103-1109 (2007)

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Cat# AP2945b
(40 western blots)
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