|Application ||WB, E|
|Other Accession||P26260, P18828, P47951, Q08DZ5|
|Predicted||Bovine, Hamster, Mouse, Rat|
|Calculated MW||32462 Da|
|Antigen Region||266-295 aa|
|Other Names||Syndecan-1, SYND1, CD138, SDC1, SDC|
|Target/Specificity||This CD138 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the C-terminal region of human CD138.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD138 Antibody (C-term K281) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).|
|Cellular Location||Membrane; Single-pass type I membrane protein. Secreted. Secreted, exosome. Note=Shedding of the ectodomain produces a soluble form.|
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Provided below are standard protocols that you may find useful for product applications.
CD138 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins.
Rikova,K., et.al., Cell 131 (6), 1190-1203 (2007)
Endo,K., et.al., J. Biol. Chem. 278 (42), 40764-40770 (2003)
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