- CITATIONS: 1
|Application ||WB, IHC-P, IF, E|
|Calculated MW||90647 Da|
|Other Names||Signal transducer and activator of transcription 5A, STAT5A, STAT5|
|Target/Specificity||This STAT5a Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y694 of human STAT5a.|
|Precautions||Phospho-STAT5a(Y694) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation|
Provided below are standard protocols that you may find useful for product applications.
STAT5a is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this protein is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells.
Martens, N., et al., J. Biol. Chem. 280(14):13817-13823 (2005).
Defilippi, P., et al., J. Cell Biol. 168(7):1099-1108 (2005).
Sekine, Y., et al., J. Biol. Chem. 280(9):8188-8196 (2005).
Sultan, A.S., et al., Oncogene 24(5):746-760 (2005).
Moriggl, R., et al., Cancer Cell 7(1):87-99 (2005).
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