- CITATIONS: 1
|Application ||DB, WB, E|
|Other Accession||P09416, Q29031, P01108, P01109, Q2HJ27, P24793, Q63379, P03966, P04198, Q9PSJ0, P18444, P15171, Q7ZVS9, P52160, P06171, Q28566|
|Predicted||Xenopus, Zebrafish, Chicken, Mouse, Rat, Bovine, Pig|
|Calculated MW||48804 Da|
|Other Names||Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39|
|Target/Specificity||This MYC Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T58 of human MYC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-MYC(T58) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growth-related genes.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, nucleolus|
Provided below are standard protocols that you may find useful for product applications.
MYC participates in the regulation of gene transcription. It binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. This protein appears to activate the transcription of growth-related genes. Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia.
Qi, Y., et al., Nature 431(7009):712-717 (2004).
Wilda, M., et al., Genes Chromosomes Cancer 41(2):178-182 (2004).
Dom, et al., Oncogene 23(44):7378-7390 (2004).
Pap, T., et al., Arthritis Rheum. 50(9):2794-2802 (2004).
Ozawa, N., et al., Endocrinology 145(9):4244-4250 (2004).
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