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> home > Products > Primary Antibodies > Antibody Collections > Phospho Antibodies > Phospho-SPRY4(Y75) Antibody
Phospho-SPRY4(Y75) Antibody
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, DB, E |
|---|---|
| Primary Accession | Q9C004 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 32541 Da |
| Gene ID | 81848 |
|---|---|
| Other Names | Protein sprouty homolog 4, Spry-4, SPRY4 |
| Target/Specificity | This SPRY4 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y75 of human SPRY4. |
| Dilution | WB~~1:1000 DB~~1:500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Phospho-SPRY4(Y75) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SPRY4 |
|---|---|
| Function | Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras (PubMed:12027893). Probably impairs the formation of GTP-Ras (PubMed:12027893). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (PubMed:12717443). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (PubMed:15584898). |
| Cellular Location | Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor) (By similarity). Colocalizes with TESK1 in vesicular spots in the cytoplasm (PubMed:15584898) {ECO:0000250|UniProtKB:Q9WTP2, ECO:0000269|PubMed:15584898} |
Research Areas
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$ 385.00
Cat# AP3585a
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