|Application ||DB, E|
|Other Accession||Q0PMD2, Q9CZ52|
|Calculated MW||62789 Da|
|Other Names||Anthrax toxin receptor 1, Tumor endothelial marker 8, ANTXR1, ATR, TEM8|
|Target/Specificity||This ANTXR1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y425 of human ANTXR1.|
|Precautions||Phospho-ANTXR1(Y425) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia|
|Tissue Location||Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells|
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Provided below are standard protocols that you may find useful for product applications.
ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Werner,E., J. Biol. Chem. 281 (32), 23227-23236 (2006)
Abrami,L., J. Cell Biol. 172 (2), 309-320 (2006)
Bradley,K.A., Nature 414 (6860), 225-229 (2001)
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