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Phospho-LINGO-1(LRRN6A)(S596) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

  • DB - Phospho-LINGO-1(LRRN6A)(S596) Antibody AP3685a
    Dot blot analysis of anti-Phospho-LINGO-1(LRRN6A)-pS596 Pab (Cat. #AP3685a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9D1T0
Other Accession Q9N008, Q96FE5, Q50L44
Reactivity Human
Predicted Chicken, Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 69101 Da
Additional Information
Gene ID 235402
Other Names Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, Lingo1, Lern1, Lrrn6a
Target/Specificity This LINGO-1(LRRN6A) Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S596 of human LINGO-1(LRRN6A).
Dilution DB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-LINGO-1(LRRN6A)(S596) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Lingo1
Synonyms Lern1, Lrrn6a
Function Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei.
Research Areas
Citations (0)

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LINGO-1 (LRR and Ig domain-containing Nogo Receptor interating protein) is a nervous system-specific LRR-Ig-containing protein with an important role in CNS biology. LINGO-1 was discovered in a sequence database search for human SLIT homologs that were selectively expressed in the brain. LINGO-1 is a transmembrane protein that is a component of the Nogo-66 receptor complex. It binds NgR1 and p75 and is an additional functional componenet of the NgR1/p75 signaling complex.


Mandai,K.,, Neuron 63 (5), 614-627 (2009)
Homma,S.,, Gene Expr. Patterns 9 (1), 1-26 (2009)

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$ 295.00
$ 99.00
Cat# AP3685a
(40 western blots)
Availability: In Stock
Bulk Size
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