|Application ||DB, E|
|Calculated MW||138579 Da|
|Other Names||Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, Neu|
|Target/Specificity||This mouse ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1051 of mouse ERBB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Phospho-mouse ERBB2(S1051) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus|
|Tissue Location||Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers|
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Provided below are standard protocols that you may find useful for product applications.
Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Binds to the 5'-TCAAATTC-3' sequence in the MT-CO2 promoter and activates its transcription (By similarity).
Cabodi, S., et al. FASEB J. 24(10):3796-3808(2010) Johnson, E., et al. J. Biol. Chem. 285(38):29491-29501(2010) Huck, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15559-15564(2010) Chuang, T.D., et al. J. Biol. Chem. 285(31):23598-23606(2010) Simeone, L., et al. J. Neurosci. 30(19):6620-6634(2010)
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