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Phospho-mouse TSC1(S1130) Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • DB - Phospho-mouse TSC1(S1130) Antibody AP3811a
    Dot blot analysis of mouse TSC1 Antibody (Phospho S1130) Phospho-specific Pab (Cat. #AP3811a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
DB, E
Primary Accession Q9EP53
Other Accession NP_075025.2
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 128746 Da
Additional Information
Gene ID 64930
Other Names Hamartin, Tuberous sclerosis 1 protein homolog, Tsc1, Kiaa0243
Target/Specificity This mouse TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1130 of mouse TSC1.
Dilution DB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-mouse TSC1(S1130) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tsc1
Synonyms Kiaa0243
Function In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Research Areas
Citations (0)

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Background

In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

References

Kladney, R.D., et al. Cancer Res. 70(21):8937-8947(2010)
Sathaliyawala, T., et al. Immunity 33(4):597-606(2010)
Scott, C.L., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 299 (4), L455-L471 (2010) :
Bartolome, A., et al. Endocrinology 151(7):3084-3094(2010)
Squarize, C.H., et al. PLoS ONE 5 (5), E10643 (2010) :

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$ 295.00
$ 99.00
Cat# AP3811a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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