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Phospho-rat TSC2(T1373) Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • DB - Phospho-rat TSC2(T1373) Antibody AP3833a
    Dot blot analysis of rat TSC2 Antibody (Phospho T1373) Phospho-specific Pab (Cat. #AP3833a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P49816
Other Accession NP_036812.2
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 201278 Da
Additional Information
Gene ID 24855
Other Names Tuberin, Tuberous sclerosis 2 protein homolog, Tsc2
Target/Specificity This rat TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1373 of rat TSC2.
Dilution DB~~1:500
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPhospho-rat TSC2(T1373) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Tsc2
Function In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth.
Tissue Location CNS, uterus, heart, skeletal muscle, kidney and spleen
Research Areas
Citations (0)

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acts as a tumor suppressor; may play a role in cell cycle regulation; acute phase response, and negative regulation of cell proliferation [RGD].


Larson, Y., et al. J. Biol. Chem. 285(32):24987-24998(2010)
Sajankila, S.P., et al. Mol. Cell. Biochem. 338 (1-2), 233-239 (2010) :
Inoue, H., et al. Biosci. Biotechnol. Biochem. 73(11):2488-2493(2009)
Di Nardo, A., et al. J. Neurosci. 29(18):5926-5937(2009)
Shiono, M., et al. Oncogene 27(52):6690-6697(2008)

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$ 295.00
$ 99.00
Cat# AP3833a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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