|Application ||WB, FC, E|
|Calculated MW||88477 Da|
|Antigen Region||212-240 aa|
|Other Names||Calcium-independent phospholipase A2-gamma, Intracellular membrane-associated calcium-independent phospholipase A2 gamma, iPLA2-gamma, PNPLA-gamma, Patatin-like phospholipase domain-containing protein 8, iPLA2-2, PNPLA8, IPLA22, IPLA2G|
|Target/Specificity||This PNPLA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the N-terminal region of human PNPLA8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PNPLA8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Cytoplasm, perinuclear region|
|Tissue Location||Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart|
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Provided below are standard protocols that you may find useful for product applications.
PNPLA8 catalyzes cleavage of fatty acids from phospholipids, thereby regulating membrane physical properties and the release of lipid second messengers and growth factors. Phospholipase A2 activity also modulates cellular growth programs, inflammation, and ion channel function.
Harper, M.T., et al. J. Thromb. Haemost. 6(10):1819-1821(2008)
Wilson, P.A., et al. J. Lipid Res. 47(9):1940-1949(2006)
Murakami, M., et al. J. Biol. Chem. 280(14):14028-14041(2005)
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