|Application ||WB, E|
|Reactivity||Human, Hamster, Mouse|
|Calculated MW||60542 Da|
|Antigen Region||217-245 aa|
|Other Names||Atlastin-3, 365-, ATL3|
|Target/Specificity||This ATL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 amino acids from the Central region of human ATL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATL3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis.|
|Cellular Location||Endoplasmic reticulum membrane; Multi- pass membrane protein. Note=Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network|
|Tissue Location||Expressed in the central nervous system and in dorsal root ganglia neurons. Expressed in peripheral tissues (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
ATL3 is GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. ATL3 is function in endoplasmic reticulum tubular network biogenesis.
Hu, J., et al. Cell 138(3):549-561(2009)
Rismanchi, N., et al. Hum. Mol. Genet. 17(11):1591-1604(2008)
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