|Application ||WB, IHC-P, FC, E|
|Calculated MW||92027 Da|
|Antigen Region||176-204 aa|
|Other Names||Advillin, p92, AVIL|
|Target/Specificity||This AVIL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-204 amino acids from the N-terminal region of human AVIL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AVIL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell projection. Cell projection, axon|
|Tissue Location||Most highly expressed in the small intestine and colonic lining. Weaker expression also detected in the thymus, prostate, testes and uterus.|
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Provided below are standard protocols that you may find useful for product applications.
AVIL is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia.
Piana, S., et al. J. Mol. Biol. 375(2):460-470(2008)
Vermeulen, W., et al. Protein Sci. 13(5):1276-1287(2004)
Tumer, Z., et al. Gene 288 (1-2), 179-185 (2002)
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