|Application ||WB, IHC-P, E|
|Calculated MW||35139 Da|
|Antigen Region||130-157 aa|
|Other Names||Ribonuclease H2 subunit B, RNase H2 subunit B, Aicardi-Goutieres syndrome 2 protein, AGS2, Deleted in lymphocytic leukemia 8, Ribonuclease HI subunit B, RNASEH2B, DLEU8|
|Target/Specificity||This RNASEH2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-157 amino acids from the Central region of human RNASEH2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNASEH2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
RNASEH2B is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. RNASEH2B is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication.
Crozat, K., et al. Immunol. Rev. 227(1):129-149(2009)
Chon, H., et al. Nucleic Acids Res. 37(1):96-110(2009)
Crow, Y.J., et al. Dev Med Child Neurol 50(6):410-416(2008)
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