|Application ||WB, IHC-P, E|
|Other Accession||Q2LAM0, Q5MPP0, Q4R4P4|
|Calculated MW||42791 Da|
|Antigen Region||121-148 aa|
|Other Names||Fatty acid 2-hydroxylase, 1---, Fatty acid alpha-hydroxylase, FA2H, FAAH|
|Target/Specificity||This FA2H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-148 amino acids from the Central region of human FA2H.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FA2H Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein|
|Tissue Location||Detected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes. Highly expressed in brain and colon Detected at lower levels in testis, prostate, pancreas and kidney|
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Provided below are standard protocols that you may find useful for product applications.
FA2H is a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups.
Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009)
Edvardson, S., et al. Am. J. Hum. Genet. 83(5):643-648(2008)
Uchida, Y., et al. J. Biol. Chem. 282(18):13211-13219(2007)
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