|Application ||WB, IHC-P, FC, E|
|Calculated MW||104930 Da|
|Antigen Region||840-868 aa|
|Other Names||Synaptotagmin-like protein 2, Breast cancer-associated antigen SGA-72M, Exophilin-4, SYTL2, KIAA1597, SGA72M, SLP2, SLP2A|
|Target/Specificity||This SYTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 840-868 amino acids from the Central region of human SYTL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYTL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1597, SGA72M, SLP2, SLP2A|
|Function||Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.|
|Cellular Location||Isoform 1: Cytoplasm. Cell membrane Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A.|
|Tissue Location||Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells.|
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Provided below are standard protocols that you may find useful for product applications.
SYTL2 is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery.
Menasche, G., et al. Blood 112(13):5052-5062(2008)
Kesari, A., et al. Am. J. Pathol. 173(5):1476-1487(2008)
Chavas, L.M., et al. Structure 16(10):1468-1477(2008)
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