|Application ||WB, IHC-P, FC, E|
|Calculated MW||104930 Da|
|Antigen Region||840-868 aa|
|Other Names||Synaptotagmin-like protein 2, Breast cancer-associated antigen SGA-72M, Exophilin-4, SYTL2, KIAA1597, SGA72M, SLP2, SLP2A|
|Target/Specificity||This SYTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 840-868 amino acids from the Central region of human SYTL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYTL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1597, SGA72M, SLP2, SLP2A|
|Function||Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol- 4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon- containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.|
|Cellular Location||Isoform 1: Cytoplasm. Cell membrane Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A.|
|Tissue Location||Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic alpha cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SYTL2 is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery.
Menasche, G., et al. Blood 112(13):5052-5062(2008)
Kesari, A., et al. Am. J. Pathol. 173(5):1476-1487(2008)
Chavas, L.M., et al. Structure 16(10):1468-1477(2008)
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