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CEP63 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CEP63 Antibody (Center) AP4805c
    CEP63 Antibody (Center) (Cat. #AP4805c) western blot analysis in WiDr,293 cell line lysates (35ug/lane).This demonstrates the CEP63 antibody detected the CEP63 protein (arrow).
  • IHC-P - CEP63 Antibody (Center) AP4805c
    CEP63 Antibody (Center) (Cat. #AP4805c) IHC analysis in formalin fixed and paraffin embedded prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CEP63 Antibody (Center)) for immunohistochemistry. Clinical relevance has not been evaluated.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96MT8
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 81344 Da
Antigen Region 520-548 aa
Additional Information
Gene ID 80254
Other Names Centrosomal protein of 63 kDa, Cep63, CEP63
Target/Specificity This CEP63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520-548 amino acids from the Central region of human CEP63.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCEP63 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CEP63
Function Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles
Research Areas
Citations (0)

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Background

CEP63 is a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells.

References

Sovio, U., et al. PLoS Genet. 5 (3), E1000409 (2009)
Weedon, M.N., et al. Nat. Genet. 40(5):575-583(2008)
Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)

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$ 295.00
$ 99.00
Cat# AP4805c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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