|Application ||WB, IHC-P, E|
|Calculated MW||81344 Da|
|Antigen Region||520-548 aa|
|Other Names||Centrosomal protein of 63 kDa, Cep63, CEP63|
|Target/Specificity||This CEP63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520-548 amino acids from the Central region of human CEP63.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CEP63 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication, through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Colocalizes with CEP152 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
CEP63 is a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells.
Sovio, U., et al. PLoS Genet. 5 (3), E1000409 (2009)
Weedon, M.N., et al. Nat. Genet. 40(5):575-583(2008)
Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)
If you have any additional inquiries please email technical services at firstname.lastname@example.org.