|Application ||WB, IHC-P, E|
|Calculated MW||81344 Da|
|Antigen Region||520-548 aa|
|Other Names||Centrosomal protein of 63 kDa, Cep63, CEP63|
|Target/Specificity||This CEP63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 520-548 amino acids from the Central region of human CEP63.|
|Precautions||CEP63 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles|
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Provided below are standard protocols that you may find useful for product applications.
CEP63 is a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells.
Sovio, U., et al. PLoS Genet. 5 (3), E1000409 (2009)
Weedon, M.N., et al. Nat. Genet. 40(5):575-583(2008)
Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)
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