|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8BFQ4, Q6NV31, Q5ZMV7, Q58E77, Q640J6|
|Predicted||Xenopus, Chicken, Zebrafish, Mouse|
|Calculated MW||35079 Da|
|Antigen Region||1-30 aa|
|Other Names||WD repeat-containing protein 82, Protein TMEM113, Swd2, WDR82, TMEM113, WDR82A|
|Target/Specificity||This WDR82 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human WDR82.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WDR82 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.|
|Cellular Location||Nucleus Note=Associates with chromatin|
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Provided below are standard protocols that you may find useful for product applications.
WDR82 is a component of the mammalian SET1A (MIM 611052)/SET1B (MIM 611055) histone H3-Lys4 methyltransferase complexes.
Wu, M., et al. Mol. Cell. Biol. 28(24):7337-7344(2008)
Lee, J.H., et al. Mol. Cell. Biol. 28(2):609-618(2008)
Higa, L.A., et al. Nat. Cell Biol. 8(11):1277-1283(2006)
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