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AGER Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP4861a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP4861a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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AGER Antibody (N-term) - Product info | |
| Application | WB, IHC, FC
|
| Primary Accession | Q15109 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 42803 Da |
AGER Antibody (N-term) - Additional info | |
| Gene ID 177 | |
| Other Names AGER; RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products | |
| Target/Specificity This AGER antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31~60 amino acids from the N-terminal region of human AGER. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 FC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions AGER Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
AGER Antibody (N-term) - Protein Information | |
| Name AGER | |
| Synonyms RAGE | |
| Function Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space | |
| Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein | |
| Tissue Location Endothelial cells. | |
AGER Antibody (N-term) - Related products
AP2401a: RAGE (AGER) Antibody (N-term)
AP2401b: RAGE (AGER) Antibody (C-term)
AP4861a: AGER Antibody (N-term)
DC04946: Human AGER cDNA Clone
LY11832a: AGER Over-expression Lysate
AGER Antibody (N-term) - Application data
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Western blot analysis of AGER Antibody (N-term) (cat. #AP4861a) in mouse lung tissue lysates (35ug/lane). AGER (arrow) was detected using the purified Pab.
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AGER Antibody (N-term) (Cat. #AP4861a) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the AGER Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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AGER Antibody (N-term) (Cat. #AP4861a) flow cytometric analysis of U251 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
AGER Antibody (N-term) - Research Areas
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BACKGROUND
AGER encodes a member of the immunoglobulin superfamily of cell surface molecules. It is a receptor for various molecules, including the amyloidogenic form of serum amyloid A, amyloid-beta protein, members of the S100/calgranulin superfamily and advanced glycation end products. The gene lies within the major histocompatibility complex (MHC) class III region on chromosome 6.
REFERENCES
Rojas, A., et al. Carcinogenesis 31(3):334-341(2010) Engelen, L., et al. J. Hypertens. 28(2):285-293(2010) Poon, P.Y., et al. Clin. Nephrol. 73(1):44-50(2010) Hancock, D.B., et al. Nat. Genet. 42(1):45-52(2010)
