|Application ||WB, IHC-P, E|
|Calculated MW||19206 Da|
|Antigen Region||144-172 aa|
|Other Names||Thioredoxin domain-containing protein 12, Endoplasmic reticulum resident protein 18, ER protein 18, ERp18, Endoplasmic reticulum resident protein 19, ER protein 19, ERp19, Thioredoxin-like protein p19, hTLP19, TXNDC12, TLP19|
|Target/Specificity||This TXNDC12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-172 amino acids from the C-terminal region of human TXNDC12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TXNDC12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Possesses significant protein thiol-disulfide oxidase activity.|
|Cellular Location||Endoplasmic reticulum lumen|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors
Jessop, C.E., et al. J. Cell. Sci. 122 (PT 23), 4287-4295 (2009)
Rowe, M.L., et al. Biochemistry 48(21):4596-4606(2009)
Jeong, W., et al. J. Biol. Chem. 283(37):25557-25566(2008)
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