|Application ||WB, FC, E|
|Calculated MW||16360 Da|
|Antigen Region||116-145 aa|
|Other Names||Phospholipase A2, Group IB phospholipase A2, Phosphatidylcholine 2-acylhydrolase 1B, PLA2G1B, PLA2, PLA2A, PPLA2|
|Target/Specificity||This PLA2G1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the C-terminal region of human PLA2G1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLA2G1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PLA2, PLA2A, PPLA2|
|Function||PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.|
|Cellular Location||Secreted. Note=secreted from pancreatic acinar cells in its inactive form|
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Provided below are standard protocols that you may find useful for product applications.
PLA2G1B catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets
Xu, W., et al. J. Biol. Chem. 284(24):16659-16666(2009)
Han, C., et al. J. Cell. Biochem. 105(2):534-545(2008)
Kao, W.T., et al. Lipids Health Dis 7, 20 (2008)
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