|Application ||WB, IHC-P, E|
|Calculated MW||61294 Da|
|Antigen Region||192-220 aa|
|Other Names||Chondroitin sulfate N-acetylgalactosaminyltransferase 1, CsGalNAcT-1, Chondroitin beta-1, 4-N-acetylgalactosaminyltransferase 1, Beta4GalNAcT-1, CSGALNACT1, CHGN, GALNACT1|
|Target/Specificity||This CSGALNACT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-220 amino acids from the Central region of human CSGALNACT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CSGALNACT1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758). Moreover, is involved in the metabolism of aggrecan (By similarity).|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein|
|Tissue Location||Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined|
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Provided below are standard protocols that you may find useful for product applications.
CSGALNACT1 transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). CSGALNACT1 required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. CSGALNACT1 is important role in chondroitin chain biosynthesis in cartilage.
Landa, I., et al. PLoS Genet. 5 (9), E1000637 (2009)
Sakai, K., et al. J. Biol. Chem. 282(6):4152-4161(2007)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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