|Application ||WB, IHC-P, FC, E|
|Other Accession||Q7TME0, NP_055654|
|Calculated MW||82983 Da|
|Antigen Region||666-695 aa|
|Other Names||Lipid phosphate phosphatase-related protein type 4, Brain-specific phosphatidic acid phosphatase-like protein 1, Plasticity-related gene 1 protein, PRG-1, LPPR4, KIAA0455, PRG1|
|Target/Specificity||This LPPR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-695 amino acids from the C-terminal region of human LPPR4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LPPR4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Specifically expressed in neurons.|
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Provided below are standard protocols that you may find useful for product applications.
LPPR4 belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting.
Trimbuch, T., et al. Cell 138(6):1222-1235(2009)
Vasan, R.S., et al. JAMA 302(2):168-178(2009)
Brauer, A.U., et al. Nat. Neurosci. 6(6):572-578(2003)
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