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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   MCL1 Antibody   

MCL1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MCL1 Antibody AP50001
    Western blot analysis of lysate from RajI cell line,using MCL1 Antibody(C0258). C0258 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.
  • WB - MCL1 Antibody AP50001
    Western blot analysis of extracts from HUVEC cells (Lane 1), JK cells (Lane 2) and COS-7 cells (Lane 3), using MCL1 Antibody. The lane on the left is treated with synthesized peptide.
  • IHC - MCL1 Antibody AP50001
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MCL1 antibody .
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q07820
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 37,29 KDa
Antigen Region 121-150 aa
Additional Information
Gene ID 4170
Other Names Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT, MCL1, BCL2L3
Dilution WB~~ 1:1000
IHC~~1:50-1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name MCL1
Synonyms BCL2L3
Function Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Cellular Location Membrane; Single-pass membrane protein. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria
Research Areas
Citations (0)

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Background

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

References

Kozopas K.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:3516-3520(1993).
Umezawa A.,et al.Cell Struct. Funct. 21:143-150(1996).
Akgul C.,et al.Cell. Mol. Life Sci. 57:684-691(2000).
Bingle C.D.,et al.J. Biol. Chem. 275:22136-22146(2000).
Bae J.,et al.J. Biol. Chem. 275:25255-25261(2000).

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$ 295.00
Cat# AP50001
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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