|Calculated MW||93 KDa|
|Antigen Region||11-39 aa|
|Other Names||Cyclin-dependent kinase 11B, Cell division cycle 2-like protein kinase 1, CLK-1, Cell division protein kinase 11B, Galactosyltransferase-associated protein kinase p58/GTA, PITSLRE serine/threonine-protein kinase CDC2L1, p58 CLK-1, CDK11B, CDC2L1, CDK11, PITSLREA, PK58|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Synonyms||CDC2L1, CDK11, PITSLREA, PK58|
|Function||Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.|
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Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression.
Bunnell B.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7467-7471(1990).
Bunnell B.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:2612-2612(1991).
Eipers P.G.,et al.Genomics 13:613-621(1992).
Xiang J.,et al.J. Biol. Chem. 269:15786-15794(1994).
Gururajan R.,et al.Genome Res. 8:929-939(1998).
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