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CD24 Antibody
Protein A Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q07490 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | H=8; M=8;R=8;35-45(actual) KDa |
| Antigen Region | 27-53aa/76aa |
| Gene ID | 25145 |
|---|---|
| Other Names | Signal transducer CD24, Heat-stable antigen, HSA, Nectadrin, CD24, Cd24, Cd24a |
| Dilution | WB~~ 1:1000 IHC-P~~1:100~1:500 IHC~~1:200 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | Cd24 |
|---|---|
| Synonyms | Cd24a |
| Function | May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin- like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. |
| Tissue Location | Expressed in the central nervous system, in postmitotic cells of spinal cord, hindbrain, midbrain and forebrain Expressed in epithelium during the development of non-neural tissues Expressed in tooth development, specifically in mesenchymal cells differentiating into odontoblast in dental papilla, as well as in the developing eye and hair follicle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells.
References
Kay R.,et al.J. Immunol. 147:1412-1416(1991).
Jackson D.,et al.Cancer Res. 52:5264-5270(1992).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Hough M.R.,et al.Genomics 22:154-161(1994).
Zarn J.A.,et al.Biochem. Biophys. Res. Commun. 225:384-391(1996).
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